Journal: Clinical and Translational Radiation Oncology

Article Title: Tomotherapy for cranio-spinal irradiation

doi: 10.1016/j.ctro.2022.11.003

Figure Lengend Snippet: Reported toxicities.

Article Snippet: Bandurska-Luque et al.,2015 , 3 , 3 , Adult , PNET MBL , 25.5–35.3 , 1.6–1.6 , Yes , Nausea Skin Hematologic , – , G3 , – , No treatment interruption.

Techniques:

Journal: Clinical Endoscopy

Article Title: Therapy of Pancreatic Neuroendocrine Tumors: Fine Needle Intervention including Ethanol and Radiofrequency Ablation

doi: 10.5946/ce.2017.167

Figure Lengend Snippet: EUS-Guided RFA for PNET

Article Snippet: Armellini et al. (2015) [ ] , 1 , PNET , 20 , 18 G, Starmed , - , 1 , Complete , - , None.

Techniques: Functional Assay

Journal: British Journal of Cancer

Article Title: An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)

doi: 10.1038/sj.bjc.6604979

Figure Lengend Snippet: Clinical characteristics of CNS PNET ( n =55, including 12 pineoblastomas) and medulloblastoma ( n =62) patient cohorts

Article Snippet: Two CNS PNETs and four pineoblastomas were obtained from CHTN.

Techniques: Biomarker Discovery

Journal: British Journal of Cancer

Article Title: An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)

doi: 10.1038/sj.bjc.6604979

Figure Lengend Snippet: Kaplan–Meier curves for analysis of the CNS PNET and medulloblastoma patient cohorts. A significant difference in overall survival was seen between CNS PNET patients under the age of 5 years at diagnosis and those over 5 years ( P =0.045) ( A ). Patients who had a complete rather than partial resection had a better prognosis (overall survival, P =0.01) ( B ). CNS PNET patients treated with both chemotherapy (CT) and radiotherapy (RT) had a significantly better progression-free survival ( P =0.01) ( C ). Medulloblastoma patients under 5 years at diagnosis also showed a significant association with survival (overall survival, P =0.006) ( D ). Medulloblastoma patients that had not relapsed ( P <0.001) ( E ) or metastasised (overall survival, P =0.01) ( F ) had a significantly better prognosis. Medulloblastoma patients treated with either radiotherapy or chemotherapy and radiotherapy also had a better outcome (overall survival, P <0.001) ( G ). All survival times are in months.

Article Snippet: Two CNS PNETs and four pineoblastomas were obtained from CHTN.

Techniques: Biomarker Discovery

Journal: British Journal of Cancer

Article Title: An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)

doi: 10.1038/sj.bjc.6604979

Figure Lengend Snippet: Results for CNS PNET and medulloblastoma immunohistochemistry cohorts

Article Snippet: Two CNS PNETs and four pineoblastomas were obtained from CHTN.

Techniques: Immunohistochemistry, Mutagenesis

Journal: British Journal of Cancer

Article Title: An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)

doi: 10.1038/sj.bjc.6604979

Figure Lengend Snippet: Immunohistochemical analysis of CTNNB1, CCND1 and MKI67 in the CNS PNET and medulloblastoma cohorts. Two patterns of CTNNB1 nuclear staining were seen in both CNS PNETs and medulloblastomas. A low level of nuclear staining (less than 10%) was seen in some CNS PNETs ( A ) and medulloblastomas ( B ). In others a high level of nuclear staining (greater than 10%) was seen ( C CNS PNET and D medulloblastoma). Over expression of CCND1 was also seen in a subset of tumours ( E , CNS PNET). MKI67 levels were measured in both cohorts ( F , CNS PNET). Levels did not correlate with CCND1. An additional CNS PNET sample containing a mutation in CTNNB1 exon 3 was analysed in a separate experiment and displayed high CTNNB1 nuclear staining ( G ).

Article Snippet: Two CNS PNETs and four pineoblastomas were obtained from CHTN.

Techniques: Immunohistochemical staining, Staining, Over Expression, Mutagenesis

Journal: British Journal of Cancer

Article Title: An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)

doi: 10.1038/sj.bjc.6604979

Figure Lengend Snippet: Schematic representation of mutation locations in exon 3 of CTNNB1 . Amino acid substitutions are indicated above the sequence; grey changes represent mutations from medulloblastoma and black from CNS PNET.

Article Snippet: Two CNS PNETs and four pineoblastomas were obtained from CHTN.

Techniques: Mutagenesis, Sequencing

Journal: British Journal of Cancer

Article Title: An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET)

doi: 10.1038/sj.bjc.6604979

Figure Lengend Snippet: Kaplan–Meier curves for analysis of CTNNB1 IHC. Comparison of CNS PNETs displaying nuclear CTNNB1 with non-nuclear staining did not reveal a significant difference in overall survival ( P =0.852) ( A ). Comparison of high CTNNB1 nuclear tumours (high nuclear) with the rest of the cohort (rest; tumours displaying low nuclear, cytoplasmic or negative staining), although not statistically significant (overall survival, P =0.113), suggested a trend towards a better prognosis for the high CTNNB1 nuclear group ( B ). A significant difference in overall survival was seen between CNS PNETs displaying high and low CTNNB1 nuclear staining (overall survival, P =0.007) ( C ). In the medulloblastoma cohort comparison of nuclear with non-nuclear CTNNB1 tumours was not significant (overall survival, P =0.590), but suggested a trend towards better survival for the nuclear group ( D ). Comparison of CTNNB1 high nuclear cases (high nuclear) with all other tumours in the medulloblastoma cohort (rest) also suggested the same trend (overall survival, P =0.310) ( E ). All survival times are in months.

Article Snippet: Two CNS PNETs and four pineoblastomas were obtained from CHTN.

Techniques: Comparison, Staining, Negative Staining